Excess weight can be difficult to reverse or treat effectively. As a result, people affected by weight gain may find it harder to lose weight regardless of diets, eating styles or physical activity.
As fat cells grow, they overproduce NNMT enzyme. This enzyme acts to slow down fat burning in our bodies. This slowdown makes it harder for these cells to burn existing fat and also makes it easier for new fat growth.
Groundbreaking research has discovered a molecule that blocks this metabolic slowdown in fat cells caused by excess NNMT. 5 amino 1 MQ block the NNMT enzyme… which is your physique’s ultimate enemy. The result of 5 amino 1 MQ: fat cell metabolism is increased!
Researchers add that by utilizing 5 amino 1 MQ, we can increase both the metabolism of current fat cells and reduce the fat cell size.
NNMT stands for nicotinamide N-methyltransferase. It is the culprit in this discussion. It becomes what is known as the domino effect; one thing leads to the next.
In this case, excess weight leads to increased NNMT enzyme leads to poor fat metabolism, which then leads to increased fat cell mass (weight gain).
The administration of this substance to obese mice resulted in a 10-day weight loss of 7% and a 30% reduction in adipose tissue compared to the untreated group, without any reduction in food consumption.
So how do we block the metabolic slowdown (or inhibit NNMT) so weight loss can occur?
Researchers tested numerous variations of methylquinolinium (MQ) to measure the effectiveness of blocking NNMT. Out of all the variations of MQ studied, 5-amino 1MQ came out on top as the most effective.
5-amino 1MQ is a small molecule that blocks the NNMT enzyme. What made it even more effective is that it did not affect the activity.
5-amino 1MQ currently is most widely used in blocking NNMT to enhance fat cell metabolism and promote weight loss.
However, NNMT has been implicated in a number of other diseases including osteoarthritis, metabolic disorders, cardiovascular disease, cancer, Parkinson’s disease, kidney disease, and other neurovascular/neurological dysfunctions.
5-amino 1MQ or another variation could be promising to treat a variety of other diseases in the future with further research.
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